Assuming the Zodiac Killer truly was inspired by the pulp magazines and comic-books, this is a strange example of life imitating art and art imitating life.

https://www.youtube.com/watch?v=vD95UZIqj-Y

https://www.denofgeek.com/movies/the-batman-riddler-riddle-in-trailer-cracked-by-amateur-sleuth/

The villain of the film, the Riddler, actually bore some similarities to Zodiac already, as both taunted law enforcement with puzzles they dared them to solve, which promised to give insight into their crimes. However, it seems as if this film is ramping up the similarities, including a cipher from the Riddler.